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Incidental ~4x4cm Lipomatous Hypertrophy of the Interatrial Septum (LHAS) in a Triple Coronary Artery Bypass Graft Surgery (CABG): Surgical and Anesthetic Considerations

Part of Topic

Introduction

Lipomatous hypertrophy of the interatrial septum (LHAS) is characterized by the histologically benign proliferation of adipose tissue that infiltrates and accumulates at the interatrial septum. A transverse diameter of >2 cm is widely referenced in the literature as the minimum septal thickness that supports the diagnosis. We present a case of LHAS discovered incidentally during a coronary artery bypass grafting (CABG) procedure, discuss the disorder's main features, the anesthetic and surgical considerations unique to the disorder, and offer a review of the existing literature.

 

Patient Presentation

Patient was a 69-year-old female with past medical history of hypertension, hyperlipidemia, and smoking here for triple vessel CABG after cardiac catheterization revealed severed triple vessel disease with reduced left ventricular ejection fraction.

HPI: She initially complained of generalized fatigue and palpitations with no associated shortness of breath or chest pain. A 12-lead ECG revealed multiple ectopic beats. Pre-op transthoracic echocardiograph (TTE) showed reduced left ventricular ejection fraction (LVEF) of 25-30% with no significant valvular dysfunction. Cardiac catheterization showed 70% stenosis in the right coronary artery, 100% stenosis in the posterior descending artery, and 70% stenosis in the left anterior descending artery, and 50% stenosis in the posterior circumflex artery. Patient was scheduled for surgery and given a defibrillating life vest until their procedure.

Anesthetic Plan

•Pre-Op: Versed
•Induction: Fentanyl, Etomidate, Propofol, Rocuronium
•Access: 2 18G hand IVs, Central Line
•Airway: 7.5mm endotracheal tube,
•Monitors: 5 Lead EKG, Portable Pacer, Pulse Ox, NIBP Cuff opposite radial arterial line, radial arterial line, Swan Ganz Catheter.
•Maintenance: TIVA with Propofol, Dexmedetomidine, Vasoactive/ByPass, Insulin Drip
•Analgesia/Anti-emetics: Ondansetron, Dexamethasone, TIVA
•Post-op Considerations: Opioids, DDD Pacing
 

Ischemia:

•Detection
•5-Lead EKG: ST depression/elevation, T-wave alteration
•Pulmonary Artery Catheter: Elevations in PCWP, New V-wave on PCWP
•Transesophageal Echocardiograph: New Regional Wall Motion Abnormality
•Treatment:
•Tachycardic: Esmolol (100-500mcg/kg), Verapamil (2.5-10mg iv)
•Hypertensive: Nitroglycerin (0.5-5 mcg/kg/min)
•Hypotensive: Phenylephrine (0.2-0.75 mcg/kg/min)
•Bradycardic: A-V Pacing

Risk Factors for LHAS:

•Obesity
•Female Sex
•Caucasian Race
•Age 60-70
•Coronary Artery Disease (CAD)
 

While the prevalence of LHAS was initially estimated to be around 2-8% in the general population, recent studies have found this figure to be as high as 43% in cardiac surgery patients. A higher prevalence has been found in patients who are obese, Caucasian, in the sixth and seventh decade of life, and women. Although LHAS is frequently a benign finding, the disorder can rarely present with a wide range of cardiac complications, including atrial arrhythmias. We present a case of large LHAS diagnosed incidentally on pre-operative imaging with subsequent successful completion of a CABG procedure. Our patient initially presented with multiple ectopic rhythm disturbances, which have been reported in association with LHAS, and sinus bradycardia in the postoperative period managed with dual chamber pacing. Our patient’s risk factors for this pathology include obesity, female sex, Caucasian race, age in the sixth-seventh decade, and coronary artery disease. As the prevalence of this disorder seems to be higher than that initially thought, it is critical for anesthesiologists to account for its potential complications in the perioperative period. Perioperative arrhythmias have been shown to prolong hospital stays and are associated with increased morbidity and mortality among patients. Arrhythmias arising under general anesthesia and in the postoperative period can be severe. While atrial arrhythmias are typically well tolerated in younger patient populations, they have been associated with life-threatening hemodynamic instability in elderly patients, the age demographic commonly presenting with LHAS. Although not displayed here, a bubble study is also to be considered as this pathology has also been associated with a patent foramen ovale (PFO). Other considerations include potential challenges with numerous surgical approaches and percutaneous interventions. Namely transseptal catheterization or bicaval cannulation.

Anesthesiologists must be aware of these potential risks and be prepared to identify and collaborate on the medical management of challenging arrhythmias or structural heart obstacles throughout the perioperative period.

 

References

1.  Laura DM, Donnino R, Kim EE, Benenstein R, Freedberg RS, Saric M. Lipomatous Atrial Septal Hypertrophy: A Review of Its Anatomy, Pathophysiology, Multimodality Imaging, and Relevance to Percutaneous Interventions. J Am Soc Echocardiogr. 2016 Aug;29(8):717-723. doi: 10.1016/j.echo.2016.04.014. Epub 2016 Jun 7. PMID: 27288088.
2.  Erhardt LR. Abnormal atrial activity in lipomatous hypertrophy of the interatrial septum. Am Heart J. 1974 May;87(5):571-6. doi: 10.1016/0002-8703(74)90494-3. PMID: 4274226.
3.Shirani J, Roberts WC. Clinical, electrocardiographic and morphologic features of massive fatty deposits ("lipomatous hypertrophy") in the atrial septum. J Am Coll Cardiol. 1993 Jul;22(1):226-38. doi: 10.1016/0735-1097(93)90839-s. PMID: 8509546.
4.Fyke FE 3rd, Tajik AJ, Edwards WD, Seward JB. Diagnosis of lipomatous hypertrophy of the atrial septum by two-dimensional echocardiography. J Am Coll Cardiol. 1983 May;1(5):1352-7. doi: 10.1016/s0735-1097(83)80151-x. PMID: 6833675.
5.Breuer M, Wippermann J, Franke U, Wahlers T. Lipomatous hypertrophy of the interatrial septum and upper right atrial inflow obstruction. Eur J Cardiothorac Surg. 2002 Dec;22(6):1023-5. doi: 10.1016/s1010-7940(02)00619-x. PMID: 12467835.
6.Myerson SG, Roberts R, Moat N, Pennell DJ. Tamponade caused by cardiac lipomatous hypertrophy. J Cardiovasc Magn Reson. 2004;6(2):565-8. doi: 10.1081/jcmr-120030585. PMID: 15137341.
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