INTRO

• ●  Knee Osteoarthritis (KOA) is a degenerative joint disease that causes functional impairment.

• ●  Intra-articular steroid or hyaluronic acid (HA) injections are often used for pain relief, but their comparative efficacy remains inconclusive.

  METHODS

• ●  Propensity score matched case-control study using TriNetX, a federated open-source database housing de-identified patient data.

• ●  Query: Five-year outcomes in KOA patients receiving hyaluronic acid (HA) or steroid intra-articular injections

• ●  Cohorts had 59,668 patients each after propensity score matching for age, race, gender, obesity, and comorbidities.

• ●  Primary outcomes included incidence of Total Knee Arthroplasty (TKA) after steroid vs HA injections

• ●  Secondary outcomes investigated rates of knee arthroscopy, further injections, falls, and opioid use after the injections.