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23rd Annual Pain Medicine Meeting 2024
November 21-23, 2024 | Caesars Palace, Las Vegas, Nevada
5799
A RETROSPECTIVE REVIEW COMPARING POST-OPERATIVE DELIRIUM IN ELDERLY PATIENTS RECEIVING KETAMINE INFUSION WITH YOUNGER PATIENTS
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Scientific Abstracts > Acute Pain
A retrospective review comparing delirium in elderly patients receiving ketamine infusion with younger patients
INTRODUCTION
●Ketamine infusions have been used widely for the treatment of acute pain. It is generally well-tolerated1.
●The incidence of Central Nervous System (CNS) adverse events is about 5% including delirium2.
●Elderly patients may be more susceptible to develop these side effects.
●We sought to compare the prevalence of adverse neurological events in elderly patients receiving ketamine infusion to the prevalence in younger adults.
●Hypothesis: ketamine infusion is associated with increased rate of delirium in elderly patients (≥ 65 years of age) as compared to younger patients (< 65 years of age).
METHODS
This study was exempt from full IRB review by the IRB at the University of Virginia. Patient records from a single tertiary care institution were analyzed from 2018 to 2023.
●Inclusion criteria - Age > 18 years, ketamine infusion > 12 hours
●Data collected: patient demographics, medical comorbidities, ketamine dose and duration, and type of surgical procedure.
●Patients with delirium were identified based on ICU-CAM score in the Intensive Care Units or addition of delirium to the active problem list on the acute care floors.
●Logistic regression models were used to examine whether the likelihood of a positive delirium diagnosis differs between elderly and younger patients, controlling for sex, surgical/non-surgical service, comorbidities of interest, dose of ketamine per IBW, and infusion duration (hours).