23rd Annual Pain Medicine Meeting 2024

Global Burden of Complex Regional Pain Syndrome: Estimates of Prevalence From 35 Countries Between 1978 and 2023

Johana Klasova¹, Chandan Saini², Albert Chang³, Stephen Music¹, Jay Dipesh Shah⁴, Praveen Reddy Elmati⁵, Ahish Chitneni⁶, Jimmy To⁷, Nasir Hussain⁸, Ryan D’Souza¹
1. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA; 2. Department of Physical Medicine and Rehabilitation, Rush University Medical Center, Chicago, IL; 3. Department of Physical Medicine and Rehabilitation, University of Washington, Seattle, WA; 4. Department of Anesthesiology, Baylor College of Medicine, Houston, TX; 5. Department of Anesthesiology and Interventional Pain, Saint Clare’s Health, Denville, NJ; 6. Department of Rehabilitation and Regenerative Medicine, New York-Presbyterian Hospital-Colombia and Cornell, New York, NY; 7. Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN; 8. Department of Anesthesiology, The Ohio State Wexner Medical Center, Columbus, OH

Introduction

Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition with prevalence ranging from 5.4 to 29 per 100,000 individuals in general population. 1-3

The global prevalence in at-risk population following an inciting event such as fracture, surgery, or neurological injury remains unknown.

We aim to address this gap by examining the global prevalence of CRPS among at-risk population from 1978 to 2023. The 12-month and 24-month prevalence were a primary outcomes

Methods

Relevant studies were identified through a systematic search following the PRISMA guidelines.

Inclusion criteria: Studies reporting CRPS prevalence in at-risk adult patients.

Estimates from individual studies were transformed using double-arcsine transformation, and the resulting estimates with 95% confidence interval (CI) were back-transformed and pooled in a meta-analysis using a random-effects model.

Results

The pooled 12-month global prevalence was 3.7% (95% CI 3.2-4.2) and the pooled 24-month prevalence was 6.1% (95% CI 5.2-7.1).

Conclusion

This meta-analysis estimated the CRPS prevalence among adults by combining data of over 2.4 million participants from 35 countries.

The global prevalence was 9.4% at 1 month, 6.9% at 3 months, 3.7% at 6 and 12 months and 6.1% at 24 months.

Most prevalence estimates were derived from developed countries highlighting the gap in CRPS research.

23rd Annual Pain Medicine Meeting 2024

GLOBAL BURDEN OF COMPLEX REGIONAL PAIN SYNDROME: ESTIMATES OF PREVALENCE FROM 35 COUNTRIES BETWEEN 1978 AND 2023

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