The COVID-19 pandemic has had an unprecedented global impact, leading to millions of cases worldwide. While much attention has been devoted to the acute phase of the illness, it is increasingly evident that post-recovery complications can significantly affect survivors' quality of life. One such complication is pleuritic chest pain. Despite the advances in COVID-19 management, the optimal approach to managing post-recovery pleuritic chest pain remains elusive, necessitating further exploration of innovative treatment modalities. However, the potential utility of SGBs in managing post-COVID pleuritic chest pain has not been extensively explored. Pleuritic chest pain in post-COVID patients can be debilitating, impairing respiratory function, hindering daily activities, and reducing overall well-being. Therefore, investigating the effectiveness of SGBs in alleviating this distressing symptom could hold significant clinical implications for improving the post-recovery care of COVID-19 survivors.

The stellate ganglion, a collection of sympathetic ganglia located at the level of the seventh cervical vertebra, plays a crucial role in regulating various physiological processes, including vascular tone and pain transmission. The use of stellate ganglion blocks (SGBs) as an interventional pain management technique has gained traction in recent years, particularly in conditions associated with sympathetic overactivity and neuropathic pain. Through the blockade of sympathetic nerve fibers, SGBs have been proven effective in providing relief for conditions such as complex regional pain syndrome, post-traumatic stress disorder, and refractory angina.

A 29-year-old male with no significant past medical history who, following COVID-19 recovery, experienced chronic pleuritic chest pain that severely impacted his daily life for two years. He had been evaluated by neurology, cardiology, gastroenterology, and pulmonology with no significant findings and was not able to find relief from conservative therapy. To address his debilitating symptoms, a stellate ganglion block was performed.