Chairside dental CAD/CAM systems have evolved and improved in all aspects since the introduction of the first CEREC machines in 1985. Because the CAD/CAM milling process does not create a smooth surface ready for clinical placement, milled restorations must be finished and polished, or glazed prior to cementation.1 A chairside polishing system used for finishing and polishing should create a smooth surface for restorations that will maintain their toughness2 and minimize the incidence of biological complications, such as bacterial adhesion and colonization, fracture or chipping of the restoration, and wear of the opposing dental enamel3 and restorations.4 A newly developed polymer-infiltrated ceramic-network (PICN) material,  Vita Enamic® (Vita Zahnfabrik, Bad Säckingen, Germany) is now available in different shades and translucencies. It is a combination of 86% sintered ceramic matrix and 14% polymer matrix, and recognized as an intermediate material between ceramic and resin composite in mechanical properties as well as physical composition. The aim of this study is to evaluate the effectiveness of five different polishing systems on a PICN material with nanoscale assessment using atomic force microscopy (AFM) and clinical visual assessment by dental students and faculty. The first null hypothesis was that ceramic and composite polishing systems would provide the same surface roughness values and surface area as the Vita Enamic® proprietary polishing system. The second null hypothesis was that all polishing systems would achieve clinically acceptable results through visual assessment.