477 posters, 14 topics, 2,065 authors, 1,055 institutions
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The Joint EBJIS-MSIS 2026 Conference
17 - 19 September, 2026 | Porto, Portugal
EP022
Efficacy of antimicrobial photodynamic therapy (aPDT) alone and in combination with antibiotics against resistant Klebsiella pneumoniae:an experimental in vitro study
Poster Presenter
Authors
Fernanda C De S E Sarti, Maria Luiza dos Santos Rodrigues, Thais Martins Goncalves, Rubens Sousa Carmo, Vinicius Renato Dos Santos Lima, Thomas Stravinskas Durigon, Cinthya Cosme Gutierrez Duran, Mauro Jose Costa Salles, Fintan Moriarty, Nilton Erbet Lincopan Huenuman, Anna Carolina Ratto Tempestini Horliana
Affiliations
Universidade Nove De Julho, S?o Paulo, Brazil; Universidade de S?o Paulo, S?o Paulo, Brasil; AO Research Institute Davos (ARI), Davos, Switzerland, Universidade Nove De Julho, S?o Paulo, Brazil, Universidade de S?o Paulo, S?o Paulo, Brasil, Universidade Federal de S?o Paulo, S?o Paulo, Brasil, AO Research Institute Davos (ARI), Davos, Switzerland, Universidade Node De Julho
Part of Topic
Basic Science
620.
Efficacy of Antimicrobial Photodynamic Therapy (aPDT) Alone and in Combination with Antibiotics against Resistant Klebsiella pneumoniae: An Experimental In Vitro Study
Fernanda C. de S. e Sarti¹,²,³*; Maria Luiza dos Santos Rodrigues¹; Thais Martins Gonçalves²; Rubens Sousa Carmo²; Vinicius Renato dos Santos Lima²; Thomas Stravinskas Durigon⁴; Cinthya Cosme Gutiérrez Duran¹; Mauro José Costa Salles⁴; Thomas Fintan Moriarty³; Nilton Erbet Lincopan Huenuman²; Anna Carolina Ratto Tempestini Horliana¹
In this in vitro model, methylene blue-mediated aPDT showed antibacterial activity against multidrug-resistant K. pneumoniae. The combination with vancomycin plus polymyxin B produced complete bacterial eradication at 1 h, whereas antibiotics alone required 24 h and aPDT alone left minimal residual growth at 24 h. These preliminary findings support further investigation of aPDT as an