Effect Of Neoadjuvant Chemotherapy On Autologous Breast Reconstruction: A Systematic Review

Purpose

Evaluate complications with NACT in autologous breast reconstruction

 

Methods

Systematic review : PubMed and Cochrane databases.

Included:

Evaluated post-operative complications of patients undergoing NACT followed by mastectomy and immediate autologous breast reconstruction

 

Conclusions

Complication rates are relatively similar.

When increased complications are seen, they are typically minor complications

Perforator dissection may be more challenging in NACT patients

The specific regimen and order of chemotherapy drugs may affect outcomes

Consideration of NACT as individual regimens especially with the advent of novel chemotherapeutics