The AAPS 102nd Annual Meeting

Does Craniosynostosis Affect Orbital Volume in Children with Graves’ Disease?

INTRODUCTION

Graves’ Disease (GD)

•Most common cause of hyperthyroidism

•Graves’ ophthalmopathy is present in 30% of patients with GD

Case:

•5-year-old with history of GD who failed medical treatment

•Consulted for possible orbital decompression

•CT findings: pansynostosis + signs of elevated ICP

•Overall impression: phenotypically similar to Crouzon syndrome

Hypotheses

1.Higher incidence of craniosynostosis in pediatric GD

2.Early suture fusion reduces orbital volume

METHODS

Retrospective Review

GD group:

•<18 years old

•+ head CT

Control group:

•age-, sex, -race-matched

•+ head CT

Suture Fusion Grading

Volumetric Analysis

•Orbital volume

•Sphenoid Volume

RESULTS

*See tables and figures.

CONCLUSIONS

Early-onset GD is associated with a higher incidence of craniosynostosis

•Potential increase in intracranial pressure

•Frontofacial advancement could offer therapeutic benefits

Orbital volume not affected

Sphenoid volume increased in older children

Does Craniosynostosis Affect Orbital Volume In Children With Graves’ Disease?