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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
13656
A Structured Ontology Of Clinical Features Applied Across Neurodegenerative Disorders
Poster Presenter
Part of Topic
Clinical Manifestations -> Neuropsychiatry and Behavioral Neurology -> Assessment and Management of Neurodegenerative disease
A structured ontology of clinical features applied across neurodegenerative disorders
Clinical features of neurodegenerative disorders have the potential to contribute to improved classification, mechanistic understanding, stratification, and prognosis. Here we present a structured ontology of individual items across distinct domains of cognition and motor function. These capture coarseand fine-grained detail of neurodegenerative syndromes.
12 higher level domains of cognitive and motor function relevant to neurodegenerative disorders weresubdivided into 336 features and organised by expert opinion.
People were recruited in Cambridge from the Quantitative MRI in NHS Memory Clinics (QMIN-MC) study and the Parkinson's Plus and Related Disorders (PrePPAReD) study
Motor and cognitive neurodegenerative syndromes, and attentional/functional cognitive disorder show differing patterns of higher level ontology domain involvement within and between syndromes.
Subdomains of the ontology demonstrate capture heterogeneity between and within cognitive and motor syndromes
Summary
Ontology features capture
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Distinct syndrome patterns
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Heterogeneity within syndromes
This structured ontology provides a novel framework to describe individual and group level clinical features of neurodegenerative disorders
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