This one-page poster presents a BVidAL Clinical Software Suite case-study workflow for review-only longitudinal tracking of neurodegenerative change using OASIS-2 longitudinal brain MRI data. Serial MRI timepoints from selected OASIS-2 subjects were imported into BVidAL SaMD beta 0.16.600606 and organized as longitudinal visit evidence. The workflow converts source MRI review outputs into geometry-based state representations for visualizing trajectory change, progression-related deviation, stability loss, and structured neurobiological review context within the Bansal Bio frameworks.

The poster demonstrates eight processed viewer MRI outputs from two longitudinal subjects, together with SaMD-generated source evidence, visit tracking, review-status, biomarker-readiness, and digital-twin readiness panels. The workflow is intended to show interpretable organization of imaging evidence across time, not to provide autonomous diagnosis or treatment recommendation. Region-specific neurodegeneration measurements, hippocampal/ventricular/cortical/whole-brain volume reporting, and final clinical interpretation require verified ROI/volume evidence, segmentation QC, and qualified reviewer sign-off.

Original data source: OASIS-2 Longitudinal MRI Data in Nondemented and Demented Older Adults. Marcus DS, Fotenos AF, Csernansky JG, Morris JC, Buckner RL. Journal of Cognitive Neuroscience. 2010;22(12):2677–2684. doi:10.1162/jocn.2009.21407.

Keywords: Alzheimer’s disease, related dementias, longitudinal MRI, neurodegeneration, clinical software, SaMD, review-only clinical decision support, BVidAL, geometry-based tracking, Bansal Bio frameworks.