**Title:** Central Venous Catheter Device Impact on Psychological Well-being and Quality of Life in Total Parenteral Nutrition Patients: A Mixed-Methods Investigation

 

**Background:** While psychological impacts of central venous catheters (CVC) in oncology patients have been documented, comparable research in total parenteral nutrition (TPN) populations is absent. Long-term TPN patients experience unique psychosocial challenges related to chronic dependence on central access.

 

**Objective:** To investigate psychological impact of CVC devices on quality of life, body image perception, and daily functioning in patients receiving home-based total parenteral nutrition.

 

**Methods:** Systematic literature review of psychological and quality-of-life impacts of central venous access devices combined with original data collection. Survey instruments (QASICC - Quality of Life and Satisfaction with Implantable Central Catheter) administered to TPN patient associations (A.N.N.A., "Un Filo per la Vita").

 

**Results:** Literature synthesis identified recurring themes: (1) daily activity limitations (hygiene challenges, mobility restrictions); (2) significant body image disturbance and intimacy concerns; (3) constant disease reminders; (4) anxiety regarding device damage/malfunction. Questionnaire data (n=multiple respondents) revealed: 59% associate device with constant illness awareness; >50% report frequent damage/malfunction fears; predominant discomfort in daily activities and social relationships; greater psychological burden in younger patients and women. Device type influences psychological impact.

 

**Conclusions:** CVC devices generate substantial psychological burden in TPN populations beyond physical management. Psychological support and evidence-based coping strategies should be integrated into standard TPN care protocols. Future research should develop and validate TPN-specific psychological intervention strategies and explore preventive approaches to minimize psychological distress.

 

**Keywords:** Central venous catheter, total parenteral nutrition, psychological impact, quality of life, body image, patient experience