The use of the Peripherally Inserted Central Catheter (PICC) has become a widely adopted alternative for medium- and long-term intravenous therapy in pediatric patients, particularly in high-complexity hospital settings. Despite its advantages such as reduced need for repeated venipunctures, the possibility of bedside insertion, and a lower risk of infectious complications compared to surgically implanted central devices, its use may still be associated with mechanical, thrombotic, and infectious complications that can compromise patient safety and the effectiveness of therapy.