Central venous access devices (CVADs) are vital to deliver treatments, monitor central-venous pressure and enable blood sampling from patients in intensive care units. However, approximately one‑quarter of CVADs fail from mechanical or infective complications.  Poor securement to the skin contributes to CVAD failure, and dressings for jugular CVADs are particularly vulnerable to pull-out forces and failure. A topical medical liquid adhesive (MLA) has been manufactured to address this problem. This study aimed to evaluate the effectiveness of MLA, compared to standard care, for improving internal jugular CVAD dressing adhesion.