The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies

Giorgia Elisabeth Colombo, Sofia Makieva, Edgardo Somigliana, Georgios Schoretsanitis, Brigitte Leeners, Christian Polli, Noemi Salmeri, Dimitrios Rafail Kalaitzopoulos, and Paola Vigano’

• Endometriosis and migraine both affect women of reproductive age with pain as a central feature [1]
• Migraine incidence rate in women is more than double the rate for men (23 per 1000 person-years compared to 10 per 1000 person-years) [1-3]
• Increasing attention is being given to the characterization of comorbidities in endometriosis to enhance clinical phenotyping
• Migraine has been reported to be significantly more common in individuals with endometriosis compared to the general population [1]
• Potential links include: hormonal milieu, inflammation, and/or genetic pre-disposition
• Aim: synthesize evidence regarding the association between endometriosis and migraine in order to inform screening, diagnosis, treatment selection, and patient education