Title:

Development and Functional Evaluation of Gallium-Carboxymethyl Cellulose Scaffolds Incorporating Chrysin: Physicochemical and Antibacterial Insights

 

Authors & Affiliations: 

• Geoffrey Khai Gin Chong¹
• Yoon Yee Then¹
• Yun Khoon Liew²
• Lai Chun Wong¹ 

¹ Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, Malaysia

² Department of Life Sciences, School of Pharmacy, IMU, Bukit Jalil, Kuala Lumpur, Malaysia 

 

Background: 

• Wound recovery is often hindered by infection and oxidative stress.
• Traditional dressings lack multifunctional protection.

 

Method Summary:

• Prepared chrysin (Chr) solutions (1, 3, 5 wt%) and Na-CMC solution (30 mg/mL).
• Gallium nitrate solution (20 mg/mL) mixed and stirred at 50 °C for 25 min.
• Washed polymer, frozen at –80 °C (24 h), then freeze-dried at –110 °C (24 h). 

 

Key Findings:

• Characterization: Enhanced porosity and swelling capacity.
• Controlled Release: Sustained chrysin release over 60 hours.
• Antioxidant Activity: Significant DPPH radical scavenging.
• Antibacterial: Effective against Staphylococcus aureus and Pseudomonas aeruginosa.
• Cell Viability: Safe for human keratinocyte (HaCaT) cells.

 

Conclusion:

Gallium-Carboxymethyl Cellulose-Chrysin (Ga-CMC-Chr) scaffolds are biocompatible, antioxidant, and antibacterial, making them promising for advanced wound healing applications that promote faster tissue repair and reduce infection risk.

 

Keywords for Search:

Gallium, Carboxymethyl Cellulose, Chrysin, Ga-CMC-Chr, wound healing, antioxidant scaffold, antibacterial dressing, tissue repair, hydrogel, biomedical material.