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The AAPS 103rd Annual Meeting 2025
May 24-27, 2025 | Austin, Texas
P52
Evaluation Of Osteointegration Of Polyetheretherketone (peek) And Amorphous Magnesium Phosphate (amp-peek) Macroporous Cranioplasty Implants In A Rat Critical-size Defect Calvarial Model
Poster Presenter
Authors
Diwakar Phuyal, Filippo Andrea Giovanni Perozzo, Mazen Al-Malak, Osama Darras, Prabaha Sikder, Varun Kshettry, Antonio Rampazzo, Bahar Bassiri Gharb
Affiliations
Cleveland Clinic Foundation, Department of Plastic Surgery, Cleveland Clinic, Cleveland, Ohio, Cleveland State University, Department of Neurological Surgery, Cleveland Clinic, Cleveland, Ohio
Part of Topic
Craniofacial/Peds
Evaluation of Osteointegration of Polyetheretherketone (PEEK) and Amorphous Magnesium Phosphate (AMP)-PEEK Macroporous Cranioplasty Implants in a Rat Critical-Size Defect Calvarial Model
Diwakar Phuyal, MB BS1, Filippo Andrea Giovanni Perozzo, MD1, Mazen Al-Malak, MD1, Osama Darras, MD1, Prabaha Sikder, PhD2, Varun Kshettry, MD1, Antonio Rampazzo, MD, PhD1, Bahar Bassiri Gharb, MD, PhD1
1Cleveland Clinic Foundation, Cleveland, OH, USA, 2Cleveland State University, Cleveland, OH, USA
Autologous bone, while biocompatible and osteoconductive, is often limited by resorption, donor site morbidity, and insufficient volume for large defects.¹
Hypothesis
We hypothesized that coating PEEK with AMP would improve its bioactivity, enhancing bone integration and implant performance. This study evaluates bone regeneration and osseointegration of AMP-coated PEEK implants in a critical-sized calvarial defect model in rodents.
Wound dehiscence : 13.3% (4/30), managed with debridement and reclosure:
Both AMP-PEEK and PEEK porous implants showed promising outcomes in bone formation and integration in a rat calvarial defect model.
AMP coating led to an increase in early bone mineral density but did not significantly improve:
Preliminary data suggest that both implant types offer mechanical resistance comparable to autologous bone.