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241 posters, 10 topics, 7 sessions, 899 authors, 296 institutions

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The AAPS 103rd Annual Meeting 2025

May 24-27, 2025 | Austin, Texas

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P50

Endoscopic Strip Craniectomy Performed Earlier Than Three Months Of Age For Nonsyndromic Craniosynostosis Has Comparable Long-term Outcomes To Later Age Surgery

Part of Topic

Craniofacial/Peds

Superior Outcomes in Endoscopic Strip Craniectomy Before Three Months of Age for Nonsyndromic Craniosynostosis

Introduction 

Management of all  craniosynostosis (CS) is primarily surgical, including both open calvarial vault remodeling (CVR) and endoscopic strip craniectomy (ESC).4 In ESC, the fused suture is excised, and barrel staves are created, both in minimally invasive fashion such that postoperative helmet, spring, or distractor device assistance allows for more gradual remodeling.5,6

 Currently, ESC is recommended for patients between 3 and 6 months of age given that rapid cranial growth and age-appropriate cranial malleability facilitate postoperative reshaping.6 However, increasing evidence suggests that surgery at even earlier ages may lead to faster deformity correction and reduced risk of neurological comorbidities.7,8 Although ESC has been successfully performed in children as young as 2 weeks of age,9 the literature supporting positive outcomes at operative ages younger than 3 months remains sparse.

Purpose

 

We sought to compare the perioperative and long-term outcomes of ESC performed for NSCS patients less than 3 months old vs. those for patients 3 months and older in order to assess the safety, efficacy, and potential advantages of providing earlier endoscopic intervention for NSCS management.

 

Methods

•All patients with nonsyndromic craniosynostosis (NSCS) who were seen at Stanford University’s Cleft and Craniofacial Clinic and underwent endoscopic strip craniectomy (ESC) with in-house postoperative helmeting between 2014 and 2021 were included. 
•All patients who had syndromic CS or suspicion of syndromic CS with ongoing genetic workup; had undergone cranial vault remodeling (CVR); or had less than 1 year of in-house postoperative follow-up were excluded.
•Age at pediatrician-initiated referral impacted age at surgery. Patients referred before 4 months of age were offered ESC. ESC could be performed up to age 6 months by parental request. All ESC cases were performed with perpendicular barrel staves.
•Patients were stratified into 2 groups based on age at surgery of < 3 months or  ≥ 3 months for retrospective record review conducted by 3 independent reviewers and including demographic information, medical history, perioperative variables, anthropometric measurements, and neurocognitive and ophthalmologic outcomes.
 
Conclusions
 

NSCS patients who underwent ESC before age 3 months demonstrated faster average operative times, a lower prevalence of anisometropia, and faster and larger changes in both their cephalic index (CI) and mediolateral (ML) dimension.

This study suggests that ESC performed before the current recommendation of at least 3 months of age is not only safe and effective, but may also lead to better perioperative, cosmetic, and neuro-ophthalmological outcomes, especially for those with sagittal craniosynostosis.

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