Cranial base morphology completes development at an early age, influencing the final position of the maxilla and mandible

Facial growth patterns in unaffected individuals can be predicted using morphometrics (lab data, unpublished)

Skeletal malocclusion (SM) in non-syndromic cleft lip and palate (nsCLP) may not be an exclusive result of the cleft or its surgical repair

Cleft and malocclusion are complex traits that share genetic and environmental factors and may present as a combined phenotype

 

Hypothesis

The malocclusion phenotype can be predicted before puberty in individuals with nsCLP