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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
13834
Pulmonary Function, Midlife Cardiovascular Health, And Cognition In The Us Khandle Study
Poster Presenter
Part of Topic
Public Health -> Epidemiology -> Risk, Reserve and Resilience
Title: Pulmonary Function, Midlife Cardiovascular Health, and Cognition in the US KHANDLE Study
Authors: Addison Leeds Berg, Rachel Whitmer, Paula Gilsanz, Alexander Ivan B. Posis
Takeaways:
➔Greater pulmonary function is associated with greater baseline cognition in an ethnoracially diverse aging cohort
◆There was no significant moderation of associations of PEF with cognition by ethnoracial group
➔Midlife cardiovascular health measures did not modify associations of pulmonary function on baseline cognition
Introduction:
- Pulmonary function is associated with cardiovascular health and later life cognition [1]. Additionally, midlife cardiovascular health (mCVH) measures can be indicative of lifelong vascular health problems [2].
- Associations between pulmonary function and cognition have not been studied in ethnoracially heterogeneous populations which have differing cardiovascular health risks [3]. Further, mCVH factors have not been investigated as potential moderators to these associations
Research Questions
- How do pulmonary function and cognition relate in different ethnoracial groups?
- Do mCVH factors moderate the effects from pulmonary function on cognition?
Methods:
Study Population: 717 KHANDLE participants
- KHANDLE is a lifecourse study of ethnic disparities in dementia epidemiology which includes midlife vascular health measures and cognitive test scores assessed for participants≥65 years old without dementia in their medical record atenrollment.
Exposure: Baseline pulmonary function
- Measured as peak expiratory flow or PEF (L/min)
Effect Modifiers: Ethnoracial group & Midlife Cardiovascular Health
- Groups categorized as Black, White, Asian, or Latino
- mCVH factors: blood pressure (mm Hg), BMI, and smoking (binary)
Outcome: Z-scored cognitive function scores
- Baseline semantic memory, executive function, and verbal episodic memory were derived from the Spanish and English Neuropsychological Assessment Scales (SENAS)
Statistical Analysis
- Multivariable linear models tested associations of PEF with each SENAS domain
- We tested moderation by ethnoracial subgroup using interactions and stratified models
- mCVH factors were tested as moderators of full cohort PEF-cognition associations
Results:
- For the full cohort, greater PEF was associated with greater baseline semantic memory, executive function, and episodic memory
- There was no evidence of effect modification by ethnoracial group on the associations between PEF and cognition in the full cohort
- Stratified models showed varying effect sizes for the association between PEF and executive function and semantic memory scores
- There were no significant associations of PEF with episodic memory in ethnoracial subgroup models
- Full cohort models showed no evidence of moderation of the associations between PEF and cognition by mCVH factors
Conclusions:
- Greater pulmonary function was associated with greater baseline cognition in a diverse ethnoracial population
- Across ethnoracial subgroups, associations between PEF and domain-specific cognition remained similar and there was no evidence of effect modification
- These findings validate pulmonary health as an indicator of cognition, possibly linked to vascular health
- mCVH did not modify the effect of PEF on cognition
- In the future, alternative pathways of association such as cardiovascular efficiency should be studied as well as longitudinal analysis of the pathways described in the present research
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