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516 posters, 59 topics, 63 sessions, 1,127 authors, 353 institutions
ePostersLive by SciGen Technologies S.A. All rights reserved.
April 29 - May 3, 2026 | Montreal, Quebec Canada

2336366
Challenging Acuity
Clinical Problem: Severe Pulmonary Hypertension in Pregnancy
WHO Class IV → Pregnancy Contraindicated
Maternal mortality: 12-16% despite modern therapies
Majority of deaths: postpartum RV failure
Why Pregnancy is Dangerous:
Physiology: Higher cardiac output, higher plasma volume
Delivery:
Autotransfusion: Abrupt preload increase (~500ml)
Relatively fixed increase in pulmonary vascular resistance
RV unable to compensate → acute RV failure
Gap in Care:
No standardized delivery strategy
High-risk periods(delivery/postpartum)
Anticipation of hemodynamiccollapse
Rapid access to advanced support
27F, G5P004, 28w EGA, severe PH (Groups 1, 4 PA 118/39 mmHg), protein S deficiency, PE, BMI 50
Admitted for medical optimization prior to scheduled CD for breech presentation
Failed initiation of IV and inhaled epoprostenol, drug-related hypoxic respiratory failure
Worsening RV failure → Uteroplacental insufficiency → Decreasing amniotic fluid index
1) Delivery Planning:
Pre-term CD in cardiac OR
Low Dose CSE
2) ECMO-Standby Strategy:
Femoral arterial and venous access
Cardiac surgeon and ECMO available
3) Advanced Monitoring
Pulmonary artery catheter (PAC)
Continuous transthoracic echocardiography (TTE)
4) RV-Protective Hemodynamic Management
Inotropy: dobutamine and epinephrine
Preload optimization:
Diuresis (Furosemide IV), therapeutic phlebotomy (800 mL via CVC)
Outcome:
Hemodynamic stability without ECMO, post-operative diuresis and inhaled NO in CVICU
Successful maternal recovery
Neonatal survival
Discharged with plan for definitive PH therapy
Impact:
1) Utilize a Tier-Based System for ECMO Care
Planning for worst-case (ECMO) improves safety andtime-to-support in decompensation
ECMO Aware, ECMO Standby, and ECMO Deployed
Helps streamline personnel available for delivery,location of delivery, and where patient will recover
2) Physiology-Guided Care is Critical
PAC + TTE + Awake Patient enable real-time feedbackand RV optimization
Tailored inotrope/volume management
3) Delivery = Hemodynamic Inflection Point
Postpartum period carries highest mortality risk
Requires aggressive, proactive management
4) Novel Strategy: Therapeutic Phlebotomy
Rapid preload reduction in immediatepostpartum period
Feasible via existing femoralaccess, hemostatic delivery, and adequatestarting hct
Potential adjunct for RV offloading