Title: The Effect of Gestational Diabetes Mellitus on Antepartum Fetal Heart Rate Monitoring.
Authors: Julie Mariam Abraham, Beth Albert, Gabriel Davis Jones.
Affiliation: Nuffield Department of Women’s and Reproductive Health, University of Oxford, England, United Kingdom.
Objective:
•Gestational diabetes mellitus (GDM) is increasingly prevalent and can lead to adverse pregnancy outcomes including fetal growth restriction and stillbirth.
•Antepartum fetal heart rate (FHR) monitoring evaluates fetal wellbeing; however, the effects of GDM on FHR patterns are poorly understood.
•We investigated whether GDM alters antepartum cardiotocography (CTG) patterns in otherwise normal pregnancy outcomes (NPO).
Design:
•This is a retrospective case-control study comparing CTGs in women diagnosed with GDM.
•Data was extracted from the Oxford Maternity dataset which includes clinical and CTG data of pregnancies recorded at Oxford University Hospitals from 1991 to 2024.
Methods:
•The GDM cohort was identified using ICD-10 codes. Those without codes for GDM, or other diabetes-related conditions, formed the control cohort.
•Propensity score matching (PSM) produced case-control pairs matched for maternal age, BMI, parity, ethnicity, fetal sex and CTG duration.
•PSM was repeated for the GDM cohort to produce separate matched groups for those GDM who were prescribed anti-hyperglycaemic medication and those who were not.
•CTG patterns included basal FHR, accelerations, decelerations, duration of episodes of high (HV) and low variation (LV), deceleration magnitude (DM), and short-term variability (STV). These were identified using the Dawes-Redman algorithm.
Key Findings:
•No significant difference in baseline FHR between groups.
•Significant increase in STV in all GDM groups.
•Significant increase in proportion of time spent in high variability in all GDM groups.
•Significant decrease in episodes of low variability in all GDM groups.
Conclusion:
•Our results suggest that GDM does affect FHR patterns.
•Recognising the impact of GDM on CTG can help us better understand the physiological impacts of GDM on fetal autonomic and cardiovascular functions.
•This could potentially help guide clinical practice to evaluate fetal wellbeing during GDM