2,281 posters, 63 videos, 56 audios, 43 topics, 18 sessions, 6,174 authors, 2,323 institutions

RCOG World Congress 2025

June 23 - 25, 2025 | ExCeL London, UK

PP.0085

Optimising the diagnosis and prognosis of sepsis in the pregnant population

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Poster Presenter

Andrea Ize-Iyamu

Authors

Andrea Ize-Iyamu, Suzannah Twiss, Cristina De La Iglesia, Elena Otero Romero, Robyn Murray, Natalie East, Catherine Evans, Katarzyna Gajewska-Knapik, Gabriela Tavares Bisinoto, Mark Johnson, Nishel Shah, Orene Greer

Affiliations

Imperial College London, University of Cambridge, Cambridge University Hospitals NHS Foundation Trust

Part of Topic

High risk pregnancy

Optimising The Diagnosis And Prognosis Of Sepsis In The Pregnant Population
Evaluation Of The Performance Of Current Clinical Tools

Background

Maternal sepsis is a syndrome characterised by organ dysfunction in the presence of infection occurring during pregnancy and in the puerperium

•Estimated global prevalence: 4.4%

•Mortality rate: 7% - severe sepsis; 60% - septic shock | Morbidity/mortality ratio: 50:1

Current sepsis prognostic tools for use in the obstetric population include:obstetrically modified SOFA (omSOFA) | obstetrically modified qSOFA (omqSOFA) | qSOFA in pregnancy (qSOFA-P) | Modified Early Obstetric Warning Score (MEOWS)

•Studies assessing the validity of these tools are limited

Aims:

•Evaluation of the performance of current diagnostic and prognostic sepsis algorithms to predict severe clinical outcomes in the pregnant population

•Determine whether a modified sepsis screening tool could successfully identify patients most at risk

Discussion

•Best performing tool of existing tools at admission: SOFA score

AUROC at admission: 0.698

AUROC at 24hrs: 0.723

•SOFA and qSOFA score outperformed their modified counterparts with peak performance elicited at 24 hours post-admission

•SSPT outperformed all existing tools at all timepoints

AUROC at admission: 0.785

AUROC at 24hrs: 0.758

Clinical Relevance

•Clinical applicability: Potential for use of SSPT in triage and on the ward

•Future directions: creation of an obstetric sepsis management pathway using various tools dependent on setting (A&E, ICU)