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RCOG World Congress 2023
June 12 - 14, 2023 | London, UK
EP.0502
The impact of Primary Ciliary Dyskinesia on female and male fertility
Poster Presenter
Part of Topic
Reproductive Medicine/Assisted Reproduction
Video
The impact of Primary Ciliary Dyskinesia on male and female fertility
Primary Ciliary Dyskinesia (PCD) is a genetic condition leading to altered structure and function of motile cilia and sperm flagellum
Infertility is commonly reported but the prognosis and optimal management is unclear
To summarise the prevalence of subfertility, underlying mechanisms, and success of ART in Primary ciliary dyskinesia
•Systematic literature searches performed in Medline, Embase, Cochrane Library, and PubMed electronic databases
Quality of evidence
Low: consisting of case reports and small cross-sectional studies
Prevalence of subfertility in PCD
Reported prevalence of fertility problems varied greatly between studies and geographic populations
Fertility problems reported more frequently in men with PCD compared to women
Underlying mechanisms
Limited evidence leads to the below proposed mechanisms
Efficacy of artificial reproductive techniques
Some men and women benefitted from artificial reproductive techniques
Suggests that use can be considered in this patient group
Success rates including live birth rate are not known
Limited evidence indicates that PCD is associated with higher risk of fertility problems and some couples may benefit from artificial reproductive techniques
Further studies are warranted to determine predictors of fertility and optimal management in this patient group