To What Extent Covid 19 Can Contribute In Premature Ovarian Failure Introduction Introduction •Premature ovarian insufficiency is a clinical syndrome defined by loss of ovarian activity before the age of 40. •The diagnosis is based on menstrual disturbance and biochemical confirmation, the diagnostic criteria is: -oligo/ammenorrhea for at least 4 months and - Elevated FSH > 25 IU/I on 2 occasions > 4 weeks apart •It can occur with 1% of population •0.1% under age of 30y •Premature ovarian failure increase Risks of; -Osteoporosis -CVS disease -Dementia -Depression -Reduce life expectancy •Most common presentation 2ry ammenorrhea, olighemenorrhea Causes Primary Causes: Chromosomal abnormalities Fsh receptor gene polymorphism And inhibit b mutation Enzyme deficiency Autoimmune diseases Secondary Causes: Chemotherapy and radiotherapy Bilateral oophorectomy or surgical menopause Hysterectomy without oophorectomy Infection Case summary &Case discussion Case Summary •27y old pt , not known to have any previous medical , surgical problems, Nor family hx of similar conditions •Presented with amenorrhea for 7 months after mild to moderate covid 19 infection •Pt had regular cycle , before her documented covid 19 infection •Her gonadotropin showed high Fsh 31 which was repeated after more than 4 wk and was found to be 29 •Her examination within normal •Send her karyotype & Thyroid profile •Some of autoimmune profile came within normal •Her pelvic us within normal also . Case discussion •Can covid 19 cause premature ovarian failure •Is there a specific finding that makes the pt more liable to premature ovarian failure after covid 19 infection. •We need more researches to discover the long term effect of covid 19 on female reproductive system Conclusion &Reference Conclusion •Young female not known to have Medical problems except Asthma on prn medication •No surgical Nor family hx of similar conditions •Suffered from premature ovarian failure around 6 to 7 month after covid 19 infection. Reference -Guideline on the management of premature ovarian insufficiency. Eshre.eu. Available from: https://www.eshre.eu/Guidelines-andLegal/Guidelines/Management-of-premature-ovarianinsufficiency -Pundir J, Coomarasamy A. Gynaecology: Evidence-based algorithms [Internet]. Cambridge, England: Cambridge University Press; 2016. Dr Reem Ahmed Eisa Elixir Medical Center, Jeddah, KSA OBS/GYN Trainee Ibrahim Malik, Khartoum, Sudan