FACTOR XII DEFICIENCY IN PREGNANCY: A CONCERN? N Patel1, L Peltola2, DN Lucas2

1 Anaesthetic trainee, LNWUH NHS Trust, London 2 Consultant Anaesthetist, LNWUH NHS Trust, London

1. Introduction

o Coagulation factor XII (FXII), is a single-chain glycoprotein in the plasma1. Its primary function is in initiating the intrinsic coagulation cascade and, therefore, is necessary for fibrin formation1.

o FXII deficiency is rare and significantly prolongs the activated partial thromboplastin time (aPTT)1. We describe a case of FXII deficiency identified in a lady presenting to labour ward with a twin pregnancy.