Lab-on-a chip Electrochemical sensing platform for Simultaneous, Ultra-Sensitive and On-spot Detection of 4-Aminosalicylic Acid and 5-Aminosalicylic Acid Based on Synergistic Potential of Chitosan functionalized MWCNTs supported on Ni doped Bi₂S₃

Abstract:

This study reports a novel electrochemical sensing platform based on chitosan-functionalized MWCNTs and nickel-doped bismuth sulphide modified screen-printed electrodes for the simultaneous real-time detection of 4-ASA and 5-ASA in urine. The sensor demonstrated low detection limits, high sensitivity, excellent recovery rates in real samples, and successful integration into a handheld device, highlighting its strong potential for point-of-care therapeutic monitoring.

https://doi.org/10.1016/j.chemosphere.2025.144425