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6425

INTRATHECAL DEXMEDETOMIDINE IN CESAREAN SECTION SPINAL ANESTHETICS AND POST OPERATIVE PAIN SCORES; A RETROSPECTIVE REVIEW

Poster Presenter

Elisa Takalo

Part of Topic

Scientific Abstracts > Regional Anesthesia

Introduction: Identifying alternative analgesic adjuvants for cesarean section spinal anesthetics is growing in popularity and necessity. Due to narcotic shortages and post operative monitoring limitations, one community hospital began routinely adding 10ug of intrathecal dexmedetomidine to their cesarean spinal anesthetics. This retrospective study compares patient’s post operative pain, opioid consumption and hypotension between patients who received hyperbaric bupivacaine only and those who received bupivacaine and 10ug intrathecal dexmedetomidine over the course of two years.  

Methods: IRB approval was obtained for this retrospective study. All women 18 and older delivered via cesarean section for the two years spanning the introduction of intrathecal dexmedetomidine were eligible for inclusion. See Figure 1 for exclusion criteria. The primary outcome measured was VAS postoperative pain scores. Secondary outcomes included morphine milligram equivalents (MME), intraoperative mean arterial pressure (MAP), and postoperative mean arterial pressure (MAP).

Key Takeaways: 

•Intrathecal dexmedetomidine reduced pain scores significantly for 6 hours after anesthesia end.
•Opioid consumption was significantly reduced for 24 hours after anesthesia in the dexmedetomidine group.
•Intrathecal dexmedetomidine did significantly increase intraoperative hypotension that persisted for 6 hours after anesthesia end.
•Intrathecal dexmedetomidine should be considered cautiously as an adjuvant in select caesarean section spinal anesthetics.
 

References
1. Shen Q-H, Li H-F, Zhou X-Y, Yuan X-Z, Lu Y-P. Dexmedetomidine as an adjuvant for single spinal anesthesia in patients undergoing cesarean section: a system review and meta-analysis. J Int Med Res. 2020;48(5):300060520913423. doi:10.1177/0300060520913423
2. Li X-X, Li Y-M, Lv X-L, Wang X-H, Liu S. The efficacy and safety of intrathecal dexmedetomidine for parturients undergoing cesarean section: a double-blind randomized controlled trial. BMC Anesthesiol. 2020;20(1):190. doi:10.1186/s12871-020 01109-4
3. Wang Y-Q, Zhang X-J, Wang Y. Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials. Drug Des Devel Ther. 2019;13:2933-2939. doi:10.2147/DDDT.S207812
4. Mo X, Huang F, Wu X, Feng J, Zeng J, Chen J. Intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during cesarean section: a prospective, double-blinded, randomized trial for ED50 determination using an up-down sequential allocation method. BMC Anesthesiol. 2023;23(1):325. doi:10.1186/s12871-023-02275-x

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