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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

10383

Longitudinal Relationship Between Depression And Hippocampal Subfield Volumes In Cognitively Unimpaired Older Adults

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Poster Presenter

Danielle Luu

Authors

Danielle Luu, Victoria Tennant, Marylan Davison, Patrick Walsh, Rajesh Nandy, Arthur Toga, Sid O'Bryant, Kristine Yaffe, Meredith Braskie

Affiliations

Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA, University of California, San Francisco, Weill Institute for Neurosciences, San Francisco, CA, 94121, USA

Part of Topic

Longitudinal relationship between depression and hippocampal subfield volumes in cognitively unimpaired older adults

Danielle Luu1, Victoria Tennant1, Marylan Davison, MS1, Patrick Walsh, MS1, Rajesh Nandy, PhD2, Arthur W. Toga, PhD1, Sid O’Bryant, PhD2, Kristine Yaffe, MD3, Meredith N. Braskie, PhD1

(1) Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, (2) University of North Texas Health Science Center, Fort Worth, TX, 76107, USA, (3) University of California, San Francisco, Weill Institute for Neurosciences, San Francisco, CA, 94121, USA

Introduction:

•Depression and Alzheimer’s Disease are both linked to hippocampal atrophy1,2

•Previously, depression was associated with smaller CA23DG volume cross-sectionally3

•We examined: 1) How depression relates to hippocampal volume across diverse ethnoracial groups and 2) How this relationship looks longitudinally?

Methods:

•Hippocampal high-resolution MRI scans (Vida or Skyra scanners) (Figure 1)

•Automatic Segmentation of Hippocampal Subfields software à subiculum, CA1, and CA23DG (region including CA2, CA3, and dentate gyrus)

•Depression = history of depression or a Geriatric Depression Scale score of ≥10

•Health and Aging Brain Study – Health Disparities (Table 1)

•Covariates: age, sex, years of education, ethnoracial group, intracranial volume, slices segmented, scanner (Table 2)

•P-values were FDR-corrected across 3 subfield regions

Results:

Linear Regression:

•Depression at baseline was associated with smaller follow-up CA23DG (B=-0.095, p=0.043) when controlling for baseline volume. Depression at baseline was associated with smaller follow-up CA1 (B=-0.074, p=0.077) and subiculum (B=-0.077, p=0.082) volumes at trend levels. (Figure 2)

LME:

•Depression was not associated with change in CA23DG volume over time (B=-0.007, p=0.429).

Discussion:

•Using linear regression and controlling for baseline volume, depression predicted lower CA23DG volume at timepoint 2. However, depression was not associated with CA23DG change using LME.

•There may be a potential external variable or insufficient timepoints for optimal LME.

•Future studies should include larger sample sizes and more timepoints.

Key Point:

When controlling for baseline hippocampal subfield volume, a depression diagnosis predicted a smaller CA23DG volume two years later.

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