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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
3335
Hypertension Improves Dementia Outcomes In Asymptomatic Carotid Disease Populations , A Multi-cohort Study
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•Blood pressure (BP) management is highly relevant for cardiovascular and brain health outcomes. Although clinical guidelines are trending towards increasingly strict BP control, some discordant results evaluating dementia-related outcomes indicate that more research is needed.
•Asymptomatic extracranial carotid atherosclerotic disease (aECAD), a hallmark cerebrovascular disease affecting >10% of those over the age of 60, may represent a key subpopulation unaccounted for in previous studies.
•In summary, hypertension appears protective in patients with aECAD for dementia-related outcomes, promoting the need for future clinical trials focusing on individualized BP goals and addressing cerebrovascular disease. Physiologically, we posit that hypertension could be a mechanism to improve cerebral perfusion in such patients.
• More broadly, these data further highlight cerebrovascular disease as relevant in brain health and aging.
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