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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
10454
Cytomegalovirus Infection And Neurovascular Damage In The Bordeaux-3C Cohort
Poster Presenter
Authors
Marie-Anne Pietrowski, Valentine Lesourd-Aubert, Pantxika Bellecave, Isabelle Garrigue, Marie-Edith Lafon, Laureline Rousseau, Gwenaëlle Catheline, Marc Joliot, Morgane Linard, Catherine Helmer
Affiliations
University of Bordeaux, INSERM, BPH, U1219, Bordeaux, University of Bordeaux, CNRS-UMR 5234 and CHU Bordeaux, Virology Department, Bordeaux, F-33000, France, University of Bordeaux, CNRS, EPHE, INCIA, UMR 5287, Talence, F-33400, France, GIN/IMN, UMR5293, Université de Bordeaux, CNRS, CEA, Bordeaux, France
Part of Topic
Introduction:
∙CMV infection is frequent and may contribute to vascular damages
∙Findings of studies on CMV infection and cerebrovascular diseases such as stroke or vascular dementia (VD) remains inconsistent
∙Few studies have examined early neuroimaging markers of vascular damages or the potential modifying roles of factors such as age, neuroinflammation, and APOE4 status
Objective:
Assess the association between CMV infection and both neuroimaging markers of vascular damage and the occurrence of stroke or VD taking into account factors could modify this association (age, neuroinflammation (via plasma glial fibrillary acidic protein (GFAP) levels) and APOE4)
In the larger study sample (N=1156 for VD) with a mean age of 74 years; 63% were women, 67% were CMV-seropositive, and 19% were APOE4 carriers.
During follow-up, 44 participants developed stroke and 31 developed VD.
CMV infection and neuroimaging markers of vascular damages:
→ Greater number of ePVS-clusters in the basal ganglia in CMV-infected participants
→ Significant interactions only with GFAP level for ePVS in basal ganglia and total WMH volume at 10 year
CMV infection and risk of stroke or VD:
We combined diagnoses of cerebrovascular disease with neuroimaging vascular markers to better characterize brain vascular health in our study. Our results showed greater neurovascular damage in CMV-infected subjects compared to non-infected ones, particularly among participants with higher levels of GFAP. Further analyses are underway to examine and understand the role of neuroinflammation in CMV effects.
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