Introduction: Progressive supranuclear palsy

(PSP) and corticobasal

syndrome (CBS) are primary

tauopathies with overlapping

motor, cognitive, and behavioral

manifestations. However, the

instruments used to assess

cognition, behavior, and clinical

severity vary widely across

studies, limiting quantitative

synthesis and direct comparison

between diagnostic groups.

Objective: To systematically

review and meta-analyze

cognitive, behavioral, and clinical

severity measures in PSP and

CBS.

Methods: 

PRISMA-based systematic review and

meta-analysis. Searches were performed

in PubMed/MEDLINE, EMBASE,

PsycINFO, Scopus, LILACS, and Google

Scholar. Study selection and data

extraction focused on cognitive,

behavioral, and clinical severity

outcomes in PSP and CBS. Random-

effects meta-analyses were conducted

for eligible outcomes, and within-study

comparative meta-analyses were

performed using Hedges’ g to quantify

PSP–CBS differences.

Conclusions: 

MMSE, MoCA, and ACE are

the most frequently used

measures in PSP and CBS.

• PSP shows worse global

cognitive performance than

CBS.

• Standardized

neuropsychological

assessment remains a

major unmet need.

• Domain-specific cognitive

measures are

underrepresented,

especially in longitudinal

studies.

• Within-study comparisons

reduce heterogeneity and

better capture PSP–CBS

differences.