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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
9972
White Matter Microstructural Integrity Predicts Future Plasma Ptau217 Change
Poster Presenter
Authors
McKenna Williams, Christine Fennema-Notestine, Emilie Reas, Tyler Bell, Divya Bolar, Donald Hagler, Olivia Puckett, Robert Rissman, Rongxiang Tang, Anders Dale, Carol Franz, Matthew Panizzon, Chandra Reynolds, William Kremen, Jeremy Elman
Affiliations
University of Southern California, University of California San Diego, University of Colorado Boulder, J. Craig Venter Institute, Texas A&M University
Part of Topic
White matter microstructural
integrity predicts future plasma
pTau217 change
KEY FINDINGS
In a community dwelling cohort of 401 men (baseline age 68):
• Better white matter microstructural integrity at baseline
predicts smaller increase in plasma pTau217 5.5 years later.
• Effects of baseline pTau217 on predicting change in white
matter microstructure were weaker and not significant.
• Results support advanced diffusion metrics in white matter
as sensitive marker of early AD-related changes.
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