4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions

Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

3019

Associations Between Stroke, Mild Cognitive Impairment And Motoric Cognitive Risk, And Post-stroke Dementia

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Poster Presenter

Emily Tirrell

Authors

Emily Tirrell, Valerie Morrill, Keenan Walker, Gabriela Gomez, Michelle Johansen, Kamakshi Lakshminarayan, B. Gwen Windham, Silvia Koton, Rebecca Gottesman

Affiliations

National Institute of Neurological Disorders and Stroke Intramural Research Program, National Institute on Aging Intramural Research Program, Mass General Brigham, Harvard Medical School, Department of Neurology, The Johns Hopkins University School of Medicine, School of Public Health, University of Minnesota, Department of Medicine, University of Mississippi Medical Center, The Stanley Steyer School of Health Professions, Tel Aviv University

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INTRODUCTION

- Stroke affects approximately 795,000 individuals in the US each year, and is a leading cause of mortality and long-term disability

- Up to a third of these patients will subsequently develop post-stroke dementia (PSD)

- The risk of milder pre-dementia syndromes post-stroke, including Mild Cognitive Impairment (MCI) and Motoric Cognitive Risk (MCR), remains poorly understood

OBJECTIVE

Evaluate 1) the association between stroke and MCI and MCR, and 2) the role of MCI and MCR in identifying individuals at risk for PSD in a large community-based cohort.

METHODS

The Atherosclerosis Risk in Communities (ARIC) Study

- A prospective cohort that enrolled individuals from four US communities

- Participants were censored at time of death, dementia, loss to follow-up or administrative censoring (Dec. 2022)

Exposure – Stroke (Ischemic or Hemorrhagic)

- Stroke was adjudicated in ARIC through hospitalization records and surveillance methods with expert physician review

Outcome – MCI/MCR, Dementia

- Four level MCI/MCR Category (None, MCI-Only, MCR-Only, Both)

- MCR: slow gait (≥ 1 SD below the population threshold (m/sec) means, adjusted for sex and age) and subjective cognitive complaints (Visit 5)

- Adjudicated MCI: in-person cognitive tests, informant interviews

- Adjudicated dementia diagnoses used in-person & telephone-based testing, informant interviews, and hospitalization codes

Statistical Analysis

- See above (Multinomial logistic: Analysis 1; Cox model: Analysis 2)

- Models adjusted for age, sex, race-center, education level, smoking, hypertension, diabetes, BMI, & APOE status

CONCLUSION

In this community-based cohort, stroke was associated with MCI, MCR, and their combination, which strongly predicted risk of post-stroke dementia. Assessing both cognitive and motoric pre-dementia conditions may provide insight into early pathways linking stroke to late-life incident dementia.

Associations Between Stroke, Mild Cognitive Impairment And Motoric Cognitive Risk, And Post-stroke Dementia

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