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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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6922

Longitudinal MEG Biomarkers Are Sensitive To The Presence, Severity And Progress Of Alzheimer's Disease

Poster Presenter

Alexandra Krugliak

Authors

Alexandra Krugliak, Marlou N Perquin, Chun Shen, Mats WJ van Es, Juliette H Lanskey, Haddy Fye, Cara Alcock, Yasir Widatalla, Melek Karadag, Ece Kocagoncu, Rebecca Williams, Andrew J Quinn, Jemma Pitt, Tony Thayanandan, Stephen Lowe, Vanessa Raymont, Krish D Singh, Mark Woolrich, Anna Nobre, James B Rowe, the NTAD study group NA

Affiliations

University of Cambridge, University of Oxford, University of Cambridge, Fudan University, University of Oxford, University of Birmingham, Lilly Corporate Center, Cardiff University, University of Oxford, Yale University, NA

Part of Topic

Longitudinal MEG biomarkers of Alzheimer’s disease: sensitivity to disease, severity and progression

Alexandra Krugliak1, Marlou N Perquin1, Chun Shen1,3, Mats WJ van Es 2, Juliette H Lanskey1, Haddy Fye1, Cara Alcock 2, Yasir Widatalla 1, Melek Karadag1, Ece Kocagoncu1, Rebecca Williams1, Andrew J Quinn3,4, Jemma Pitt2,  Tony Thayanandan2, Stephen Lowe5,  Vanessa Raymont2, Krish D Singh6, Mark Woolrich2, Anna C Nobre2,7, James B Rowe1, the NTAD study group. 

1 University of Cambridge, 2 University of Oxford, 3 Fudan University,4 University of Birmingham, 5 Lilly Corporate Center, 6 Cardiff University, 7 Yale University

 

An academic-industry collaboration with multi-center longitudinal studies with harmonized MEG protocols to test the sensitivity and reliability of M/EEG biomarkers of AD:

•NTAD: New Therapeutics in Alzheimer’s Disease study1
•SHINE: Synaptic Health in Neurodegeneration
•DFP: Deep and Frequent Phenotyping2
 

Magnetoencephalography (MEG)

 

MEG tasks:

Roving mismatch negativity

•MEG responses to unexpected sounds
 

Audio-visual oddball task

•Associative-mismatch paradigm
•MEG responses to unexpected sounds based on associative learning
 

Audio-visual motor-task

•Tests early sensory MEG responses
•Control task
 

Scene repetition task

•Passive memory test
•MEG responses to repeated items
 

Resting state:

•Eyes open
•Eyes closed
•Spontaneous brain activity
 
 
Conclusion:

MEG based biomarkers to AD are sensitive and reliable to detect the presence, severity, and progression of AD.

With this level of reliability we propose that MEG is suitable to support experimental medicine studies of AD/MCI.

 

The data will be made available via the DPUK Data Portal: https://portal.dementiasplatform.uk/

 

References:

NTAD protocol paper:
1.Lanskey JH, Kocagoncu E, Quinn AJ, Cheng YJ, Karadag M, Pitt J, Lowe S, Perkinton M, Raymont V, Singh KD, Woolrich M, Nobre AC, Henson RN, Rowe JB; NTAD study group. New Therapeutics in Alzheimer's Disease Longitudinal Cohort study (NTAD): study protocol. BMJ Open. 2022 Dec 15;12(12):e055135.
 
DFP protocol paper:
2.Koychev I, Lawson J, Chessell T, Mackay C, Gunn R, Sahakian B, Rowe JB, Thomas AJ, Rochester L, Chan D, Tom B, Malhotra P, Ballard C, Chessell I, Ritchie CW, Raymont V, Leroi I, Lengyel I, Murray M, Thomas DL, Gallacher J, Lovestone S. Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease. BMJ Open. 2019 Mar 23;9(3):e024498.
 

Roving mismatch negativity:

3.Lanskey JH, Jafarian A, Hughes LE, Karadag M, Kocagoncu E, Rouse MA, Adams NE, Naessens M, Raymont V, Woolrich M, Singh KD, Henson RN, Rowe JB. Alzheimer's disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography. Mol Psychiatry. 2026 Mar;31(3):1587-1596.   doi: 10.1038/s41380-025-03288-3.

4. Lanskey JH, Jafarian A, Karadag M, Kocagoncu E, Williams RS, Yadav P, Quinn AJ, Pitt J, Thayanandan T, Lowe S, Perkinton M, Timmers M, Raymont V, Singh KD, Woolrich M, Nobre AC, Henson RN, Rowe JB. Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity. Alzheimers Dement. 2025 Oct;21(10):e70805   doi: 10.1002/alz.70805.
 

Reliability of MEG:

•Jafarian A, Assem MK, Kocagoncu E, Lanskey JH, Williams R, Cheng YJ, Quinn AJ, Pitt J, Raymont V, Lowe S, Singh KD, Woolrich M, Nobre AC, Henson RN, Friston KJ, Rowe JB. Reliability of dynamic causal modelling of resting-state magnetoencephalography. Hum Brain Mapp. 2024 Jul 15;45(10):e26782.   doi: 10.1002/hbm.26782.

 

 

 

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