Characterizing Arachnoid Cutoff Exit Points in Aging and Alzheimer’s Disease.

Specialized barriers, including the blood-brain barrier, shield the central nervous systems (CNS) from the peripheral immune system. Yet, CNS-dura communication is vital for immune surveillance and waste clearance.

ACE points are sites where bridging veins cross the arachnoid into the parasagittal dura as potential routes for waste and immune cell transport.

Older adults (65+) from the Knight Alzheimer’s Disease Research Center (ADRC) will undergo a pre- and post-contrast MRI that will be aligned with their existing amyloid PET scan.