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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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9791

Region-agnostic Staging Of Tau Pathology Using The PET-only Tau-MaX Pipeline

Part of Topic

•2024 AA Workgroup Criteria use combination of spatial extent and magnitude of tau pathology to define biological stages
•Discrete stages are made up of heterogeneous populations with large overlap between groups
•Not all individuals may fit within the canonical progression for standard staging
•Inconsistent approaches to operationalizing criteria, with many opting for spatial extent-only methods
•Objective: Use Tau-MaX to evaluate spatial extent and magnitude along Biological stages and generate continuous Tau Timeline contextualized within AA staging system
 
•Tau-MaX provides a continuous measure of magnitude and extent that captures biological severity along AA working group stages
•The Tau timeline provides a continuous means for assessing tau severity and can be contextualized within AA working group biological stages

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