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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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6430

Effect Of Parity And ί-amyloid On Cognition And Hippocampal Volume In Postmenopausal Women

Part of Topic

•Being biologically female is one of the main risk factors of AD1. Females who develop AD show a worse cognitive trajectory after mild cognitive impairment (MCI) diagnosis 2  and a faster atrophy rate in the hippocampus 3
•Pregnancy causes major hormonal changes which impact immune 4, cardiovascular 5 and endocrine systems 6.
•Epidemiological studies looking at parity and AD risk yield mixed results7, 8
•Only 2 studies have investigated the impact of pregnancy on AD whilst including biomarkers, and their results are mixed
 
Aim:

To test whether parity interacts with Aβ load in its association with cognitive decline and HV

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