Investigation of wake slow waves (SW, sleep-like SW in wake EEG often interpreted as intrusions of local sleep during wakefulness) in 274 older adults with subjective cognitive decline (SCD).

1) Do wake SW cross-sectionally relate to cognition?

2) Can wake SW predict the transition to amyloid positivity (A+, assessed with TEP 18F-florbetapir) in the next years?

--> Higher wake SW amplitude at rest was correlated with poorer memory performance.

--> Wake SW amplitude yielded good performance for predicting which individuals will convert to A+ in the next 2 years.

Wake SW may serve as an early EEG biomarker of AD pathology and help identifying amyloid negative (A-) individuals at risk of transitioning to A+, even before the onset of objective cognitive decline.