4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions

Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

6242

Digital Biomarkers Of Physical Activity Enable Longitudinal Measurement Of Disease In Progressive Supranuclear Palsy

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Poster Presenter

Anne-Marie Wills

Authors

Anne-Marie Wills, Ram Kinker Mishra, Alexander Pantelyat, Kyurim Kang, İlkay Yıldız Potter, Rylee Cole, Tejas Pawar, Charlie Weige Zhao, Ashkan Vaziri

Affiliations

Massachusetts General Hospital, Harvard Medical School, BioSensics, Johns Hopkins School of Medicine

Part of Topic

PSPRS increased ~30% over 12 months, confirming progressive clinical deterioration.

Step duration variability increased throughout follow-up, reflecting worsening gait instability.

Standing percentage declined by ~27%, suggesting reduced mobility and functional capacity.

Wearable biomarkers tracked the direction of PSPRS progression, supporting their validity as objective digital biomarkers..

The largest changes occurred after 6–12 months, indicating this interval is likely most informative for detecting disease progression.

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