4,068 posters, 219 videos, 101 topics, 69 sessions, 14,365 authors, 6,128 institutions
ePostersLive by SciGen Technologies S.A. All rights reserved.
Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
10327
Behavioral And Neurochemical Abnormalities In Humanized Tau-FAD Combination Mice
Poster Presenter
Authors
Kumar Sambamurti, Piyush Padhi, Manikandan Samidurai, Miguel Pappolla, Debomoy Lahiri, Nigel Greig, Sumit Sarkar, Gregory Phillips, Anumantha Kanthasamy
Affiliations
Neuroscience, Medical University of South Carolina, Charleston, SC, USA, University of Georgia, Athens, GA, USA, Neuroscience, University of Texas, Galveston, TX, USA, Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, National Institute on Aging, NIH, Baltimore, MD, USA, Neuroscience, FDA, Little Rock, AR, USA
Part of Topic
The HTAP2 mouse model combines AD pathology by integrating human MAPT with FAD mutations and exhibits behavioral and catecholaminergic deficits.
Engineered E. coli Nissle enables sustained in vivo L-DOPA production, providing continuous 6–8 h delivery and avoiding pharmacokinetic peaks of standard therapy.
Restores monoaminergic deficits and is well tolerated, supporting a promising, translational microbial-based therapeutic strategy under active investigation.
Comments
Email is required but is not shown publicly.
Loading comments...