Socioeconomic deprivation is a well-established determinant of dementia risk, morbidity, and mortality. Whether this also affects survival in people with a specific diagnosis of frontotemporal lobar degeneration (FTLD) remains poorly understood, particularly the relative contribution of individual-level characteristics compared with area-level deprivation measures.

We identified that individual-level clinical and social vulnerability factors, particularly living alone, age, specific FTLD diagnosis, and comorbidities, are primary drivers of survival outcomes in FTLD syndromes, outweighing the influence of neighbourhood-level deprivation. These findings argue for personalised care models that directly address modifiable individual risks.