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Alzheimer's Association International Conference 2026

July 12-15, 2026 | London, United Kingdom, and Online

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6121

Asymptomatic Carotid Stenosis Is Associated With Processing Speed And Executive Function Deficits Which Correlate With Ptau217.

Poster Presenter

Summan Zahra

Authors

Summan Zahra, Scott French, Juan Arias, Haley Wiskoski, Madeline Ally, Cris Escareno, Emma Heitkamp, Frenchell Vasquez, Gavin Culwell, Francesca Vitali, Edward Bedrick, Raza Mushtaq, Maria Altbach, Ted Trouard, Eric Reiman, Gene Alexander, Craig Weinkauf

Affiliations

University of Arizona, Banner Alzheimer's Institute, Barrow Neurological Institute

Part of Topic

BACKGROUND

•Asymptomatic carotid stenosis has been associated with increased Alzheimer’s disease (AD) risk, but the earliest cognitive changes in this hallmark vascular disease population and its association with AD pathology are largely unknown. 
•We wanted to determine what neurocognitive measures are associated with asymptomatic carotid disease and whether these measures correlate with AD pathology.
 
RESULTS

Carotid Stenosis is associated with poorer performance on processing speed and executive function domains*.

Carotid cognitive index comprising WAIS-IV Coding, Stroop C-W Interference and Trails A was significantly associated with carotid stenosis independent of potential confounders.

Carotid cognitive index correlated significantly with AD biomarker, plasma pTau217.

CONCLUSION

•Cognitive dysfunction in the processing speed and executive domains associated with carotid stenosis correlate with AD pathology and complement and contrast the memory domain changes associated with a classic notion of Alzheimer’s dementia. .
•Although patients with carotid disease are not regularly evaluated clinically for cognitive impairment or dementia, this work builds momentum for clinical management changes and future studies with a long-term goal of dementia prevention.

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