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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
1956
Brain Edge-centric Network Reveals Superior Temporal Gyrus Pathway As A Biomarker For Language-impaired Mild Cognitive Impairment
Poster Presenter
Authors
Lin Huang, Wenjing Hu, Luyao Wang, Chu-Chung Huang, Fang Xie, Jiehui Jiang, Yang Wang, Qihao Guo
Affiliations
Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China, Radiation Oncology Center, Huashan Hospital, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, China, Institute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, 200444, China, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China, Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China
Part of Topic
Language-impaired mild cognitive impairment (ilMCI) is a heterogeneous pre-dementia stage, driven by distinct pathological mechanisms. We identified bilateral superior temporal gyrus edge-centric functional connectivity as a cross-culturally robust imaging biomarker for ilMCI. Integrating this imaging feature with plasma GFAP achieved an AUC of 0.835 for early pathological subtyping of ilMCI.
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