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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
9018
Physical Activity Is Associated With Trajectories Of Blood-based Biomarkers Of Neurodegeneration: Findings From The Rhineland Study
Poster Presenter
Authors
Eva Saxler, Rika Etteldorf, Monique M.B. Breteler, N.Ahmad Aziz
Affiliations
German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases; University of Bonn, University Hospital Bonn, Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), German Center for Neurodegenerative Diseases; University of Bonn, University Hospital Bonn, Institute for Medical Biometry, Informatics and Epidemiology (IMBIE); University of Bonn, University Hospital Bonn, Center of Neurology, Department of Parkinson, Sleep and Movement Disorders
Part of Topic
In a populatiion-based cohort, we measured accelerometer-derived physical activity at baseline and levels of three blood-based biomarkers over time (glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (pTau217)).
Higher sedentary times were associated with higher average levels of GFAP.
Higher step counts and energy expenditure were associated with reduced age-related increases of NfL.
More time spent in moderate-to-vigorous physical activity was associated with lower average levels of pTau217 and slower age-related increases of pTau217.
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