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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
1779
Multidimensional Workplace Stressor Profiles And Cognitive Trajectories In Diverse Older Adults
Poster Presenter
Authors
Monica Walters, Kiana Scambray, Jordan Palms, Robrielle Pierce, Ketlyne Sol, Laura Zahodne
Affiliations
Part of Topic
INTRODUCTION
•Occupational exposures: understudied component of dementia exposome
•Individual occupational exposures relate to cognitive health. Less is known:
•Exposure to multiple occupational stressors
•Whether stressors may cluster across occupations
•Presence of racial disparities in exposures and associations
•AIM 1: Characterize distribution of multidimensional workplace stressors
•AIM 2: Relate profiles of stressors to cognitive health trajectories
•AIM 3: Characterize differences by race
METHODS
•Up to 3 waves of longitudinal data from 704 participants from the Michigan Cognitive Aging Project (time between waves: M=2.5±2.2 years; range=0-7.1)
•26 occupational stressors linked based on main lifetime occupation
•Occupational Information Network (O*NET)
•242 unique occupation codes represented
•Latent profile analysis: detect distinct profiles of occupational stressors
•Latent growth curve modeling assessed how profiles related to cognition (Figure 1)
RESULTS
•Aim 1: 5 unique profiles emerged (Figure 2) that exhibited differences in sociodemographics (Table 1)
•Aim 2:
•Profile 3 had lower initial cognition than Profile 1 (b=-0.22, 95% CI [-0.39, -0.05])
•Profile 2 had faster cognitive decline than Profile 1 (b=-0.05, 95% CI [-0.09, -0.01])
•Aim 3:
•Black participants were more likely to belong to more stressful profiles (RRRs from 1.95-3.12, p <.05); controlling for education nullified effects
•Profile 3 related to worse initial cognition among Black participants only (Figure 3)
DISCUSSION
•Occupations have distinguishable stressor exposures that have differential impacts on cognitive trajectories
•Workplace disengagement/limited job opportunities and social stress may be particularly detrimental to cognitive health
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