Background: 

Occupational exposome: totality of all working conditions and contexts over the life-course

Lewy Body Dementia (LBD):

Knowledge Gap: Link between high job strain and LBD neuropathology

Methods:

Study Sample: Brain donors from two brain banks with occupational histories (n=999; donations: 1985-2018)

Occupational Exposome Determination:

"Job Strain="  "Job Demand" /"Job Control" 

Outcome: Presence of Lewy body neuropathology

Covariates: Age, Sex

Statistical Analyses: Multivariate logistic regression models

Discussion:

The adverse occupational exposome via high job strain linked to greater odds of Lewy body neuropathology

Demonstrated novel approach for linking occupational histories and exposures to brain bank cohorts is feasible

Limitations: Biased representation of U.S. population

Impact: Leveraging the modifiable occupational exposome via high job strain to target vulnerable individuals and communities with risk reduction strategies at structural/policy- or individual-level

Next Steps: Replicate study in larger, more diverse brain bank and greater characterization (timing and dose) of high job strain exposure.

Conclusions:

The fundamentally modifiable occupational exposome is linked to Lewy body neuropathology providing tremendous opportunity to reduce or mitigate risk for Lewy body neuropathology earlier in the life-course.

Acknowledgements:

This research was supported by the National Institute on Aging of the National Institutes of Health (NIH) under grant numbers K00AG083275 (principal investigator [PI], Dr Lee; co-PI, Dr Kind), R21AG079277 (PI: Powell), R01AG070883 (PI, Dr Kind; MPI, Dr Bendlin), P30AG062715 (PI, Sanjay Asthana, MD; Core H Leader, Dr Kind), and P30AG062429 (PI, James B. Brewer, MD, PhD).