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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
1381
Non-flickering 40 Hz Light Improves Memory Performance And Gamma Activity In Cognitively Unimpaired Older Adults
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Introduction
•Previous studies showed that 40 Hz flickering light could reduce amyloid-beta pathology in animal models of AD and may attenuate hippocampal atrophy in humans.
•However, flickering light often causes visual discomfort, limiting long-term adherence.
•Non-flickering 40 Hz light technologies have been developed to improve tolerability, but their efficacy remains unclear.
•This study evaluated the intervention effects of a novel non-flickering 40 Hz light on cognition and resting-state EEG (including power spectral density [PSD] and functional connectivity [FC]) in cognitively unimpaired older adults.
Methods
•Subjects received light stimulation for 1 hour/day, 7 days/week, over 4 weeks using a LED panel (Aleddra, Inc.).
Results
•Following the intervention, no significant differences between the 40 Hz and 70 Hz groups were observed in resting-state gamma-band EEG PSD or FC.
•Participants receiving 40 Hz light showed greater improvements in delayed recall on the Chinese Version Verbal Learning Test and the Complex Figure Test (CFT) than those receiving 70 Hz light.
•Improvements in visuospatial memory (i.e., CFT) were linked to increases in occipital–temporal imaginary coherence (ImCoh, p = 0.009).
•Real-time EEG recordings from a subset of subjects demonstrated robust 40 Hz activity across widespread cortical regions during stimulation.
Conclusion
•Non-flickering 40 Hz light stimulation may enhance episodic memory in cognitively normal older adults. The dissociation between behavioral and neural findings suggests individualized neural responses to gamma-frequency stimulation.
Take-home message
•Memory improved without group-level EEG changes, but individual memory gains tracked connectivity changes.
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