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Alzheimer's Association International Conference 2026
July 12-15, 2026 | London, United Kingdom, and Online
6187
Brain Metabolic Protection Conferred By The APOE3Ch Mutation In Normal Aging
Poster Presenter
Authors
Catarina Tristão-Pereira, Vincent Malotaux, Yesica Zuluaga, Claudia Munoz, George Silva, Bing He, Diana Alzate, Yamile Bocanegra, Alejandro Guerrero, Laura Serna, Carolina Ospina, Monica Vidal, Sergio Alvarez, Rafael Posada-Duque, Joseph Arboleda-Velasquez, David Aguillon, Yakeel T. Quiroz
Affiliations
Department of Psychological and Brain Sciences, Boston University, MA, USA, Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Colombia, Hospital Pablo Tobón Uribe, Colombia, Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, MA, USA
Part of Topic
Introduction:
The APOE3 Christchurch (APOE3Ch) is a rare genetic variant associated with marked protection against autosomal dominant Alzheimer’s disease (ADAD) due to the PSEN1E280A variant (1,2)
To investigate age-related alterations in cerebral glucose metabolism and cognitive function in:
APOE3Ch-PSEN1E280A carriers had a 58% smaller age-related reduction in precuneus metabolism, along with a 50% smaller reduction in episodic memory, compared to typical PSEN1E280A carriers
Across the adult lifespan, APOE3Ch carriers had preserved glucose metabolism in the ACC compared to non-carriers (slope: 0.001 vs -0.009), which correlated with greater global cognition and episodic memory and fewer memory complaints and depressive symptoms.
The APOE3Ch variant may be protective against brain metabolic changes both in ADAD and across the disease-free adult lifespan, with corresponding benefits in cognitive function.
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