•Being biologically female is one of the main risk factors of AD1. Females who develop AD show a worse cognitive trajectory after mild cognitive impairment (MCI) diagnosis 2  and a faster atrophy rate in the hippocampus 3

•Pregnancy causes major hormonal changes which impact immune 4, cardiovascular 5 and endocrine systems 6.

•Epidemiological studies looking at parity and AD risk yield mixed results7, 8

•Evidence from rodents tells us that APOE-ε4 carriership may affect the long-term effects of parity on neuroanatomical changes over the lifespan, but this has not been studied in humans9 .

 

Aim: 

To test whether parity interacts with APOE-ε4 in its association with cognitive decline and HV